Interologs

ProCope contains a set of methods to calculate and score interologs.  The basic assumption for this type of interaction is that homologs of interacting proteins have a high probability of being interaction partners as well. These homology-derived potential interactors are then called interologs. The methods implemented in ProCope are taken from a publication by Yu et al., 2004.

To calculate interologs, a given protein interaction network and a protein mapping (usually homology information) is used as input. The protein mapping is represented as a directed network where each directed edge represents one protein/protein mapping. Protein interactions are mapped and the resulting transferred interactions scored using the original BLAST evalues or pairwise alignment scores of the homologs.

The GUI and command line of ProCope do not include interolog calculation. Check out the JavaDocs of the procope.methods.interologs package to find out how to access the methods programatically.


ProCope documentation