@article {bioinflmu-1324,
	title = {{RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.}},
	journal = {Nature communications},
	volume = {6},
	year = {2015},
	month = {2015},
	pages = {7367},
	abstract = {The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3{\textquoteright}UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify \~{} 3,800 mRNA targets with >16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed a structure-sequence motif with U-rich sequences embedded in hairpins. RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs, indicating a role of this RNA-binding protein in the post-transcriptional regulation of the DNA damage response. Intriguingly, RC3H1 affects expression of the NF-κB pathway regulators such as IκBα and A20. RC3H1 uses ROQ and Zn-finger domains to contact a binding site in the A20 3{\textquoteright}UTR, demonstrating a not yet recognized mode of RC3H1 binding. Knockdown of RC3H1 resulted in increased A20 protein expression, thereby interfering with IκB kinase and NF-κB activities, demonstrating that RC3H1 can modulate the activity of the IKK/NF-κB pathway.},
	doi = {10.1038/ncomms8367},
	url1 = {<a href="http://www.nature.com/ncomms/2015/150714/ncomms8367/full/ncomms8367.html">Journal link</a>},
	author = {Yasuhiro Murakawa and Michael Hinz and Janina Mothes and Anja Schuetz and Michael Uhl and Emanuel Wyler and Tomoharu Yasuda and Guido Mastrobuoni and Caroline C. Friedel and Lars D{\"o}lken and Stefan Kempa and Marc Schmidt-Supprian and Nils Bl{\"u}thgen and Rolf Backofen and Udo Heinemann and Jana Wolf and Claus Scheidereit and Markus Landthaler}
}