@article {bioinflmu-364,
	title = {{Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses}},
	journal = {Clin Orthop Relat Res},
	number = {427 Suppl},
	year = {2004},
	pages = {138-143},
	abstract = {Functional genomics is a challenging new way to address complex
diseases such as osteoarthritis on a molecular level. This complements previous
research and will open up new areas of so far unrecognized molecular networks. In
this respect, articular cartilage is a good target for functional genomics as it
contains only one cell type to which all expression signals can be attributed to.
Despite considerable limitations at present, such as a low sensitivity and
insensitivity to alternative splicing, posttranscriptional regulation, and
posttranslational modification, cDNA-array technology provides a powerful tool to
obtain an overview on gene expression patterns hardly achievable with other
techniques. This has been shown to be true for known genes as well as for the
identification of new genes of interest. Therefore, gene expression analysis will
help to identify single genes depending on the disease and experimental
conditions investigated. However, the expression pattern of the plethora of
expressed genes will paint a picture (network) of disease context, maybe even
more pushing forward our understanding of complex diseases such as
osteoarthritis.},
	keywords = {*Genomics, Cartilage Articular, Humans, Models Genetic, Osteoarthritis/*genetics, Research Support Non-U.S. Gov{\textquoteright}t},
	author = {Thomas Aigner and E. Bartnik and F. Sohler and Ralf Zimmer}
}