@article {bioinflmu-568,
	title = {{From ORFeomes to protein interaction maps in viruses}},
	journal = {Genome Res},
	volume = {14},
	number = {10B},
	year = {2004},
	pages = {2029-2033},
	abstract = {Although cloned viral ORFeomes are particularly well suited for

genome-wide interaction mapping due to the limited size of viral genomes, only a

few such studies have been published. Here, we summarize virus interaction

mapping projects involving vaccinia virus, hepatitis C virus (HCV), potato virus

A (PVA), pea seed-borne mosaic virus (PSbMV), and bacteriophage T7, as well as

some projects in progress. The studies reported suggest that virus-specific

coding and replication strategies must be taken into account to yield accurate

numbers of protein interactions. In particular, the number of false negatives can

be significant for RNA viruses expressing precursor polyproteins (because

interactions between full-length mature proteins are often not detected due to

incorrect processing) and for viruses replicating in the cytoplasm whose

transcripts have not been selected for splicing signals. In conclusion, the

studies on viral protein interaction maps suggest that cloned pathogen ORFeomes

will contribute to a holistic picture of the pathogenesis of infectious diseases

and are ideal starting points for new approaches in systems biology. Both viral

ORFeome and interaction mapping projects are being documented on our Web site

(http://itgmv1.fzk.de/www/itg/uetz/virus/).},
	doi = {10.1101/gr.2583304},
	pdf = {<a href="/files/oldwebfm//Publications/From_ORFeomes_to_protein_interaction_maps_in_viruses.pdf">PDF</a>},
	author = {Peter Uetz and Seesandra V. Rajagopala and Yu-An Dong and J{\"u}rgen Haas}
}