Lehr- und Forschungseinheit Bioinformatik




Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for COVID-19 and has been in the focus of the public and research community since 2020. Viral miRNAs are expected to play a role in the molecular mechanisms SARS-CoV-2 utilizes to replicate and evade immune evasion in the host cell. Several articles with both predicted and experimentally validated miRNAs have been published so far. Yet, those potential SARS-CoV-2 encoded miRNAs are not part of the common miRNA databases. With a text mining approach and subsequent manual extraction and curation, we were able to source an up-to-date and quite comprehensive collection of potential viral miRNAs, which we want to present to the scientific community to advance further research. The collection contains 564 miRNAs (as of 10.04.2022) Since not all miRNAs were experimentally verified, the collection might contain false positives, but it is highly sensitive.

The collection is available as a synonym list (Syn List), that can be used for textmining (as described in our recent publication, soon available) and as a fasta file. For the synonym list, the entries start with a miRNA name, given by the authors of the respective publications, and are then followed by synonym miRNA names, which are previously collected miRNA entries with the same sequence. The amount of columns, i.e. synonyms is variable, but the last two entries for each miRNA are the sequence, in both U and T version, since both versions are found in the literature.
The fasta file contains the miRNA names in the fasta header, synonym names used by different authors are seperated by a "|", the next line contains the miRNA sequence in U notation. The sequences were taken from the original publications and only modified by exchanging "T" with "U" if needed.

Syn List synonymlist.txt
miRNA FASTA mirnawithinvs.fa


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